Where To Buy Huperzine A High Quality
The most obvious domain that would benefit from enhanced functioning by huperzine supplementation is perceptual-motor function. This is a more broad term for hand-eye coordination that extends to all sensations and body part. For example, you can follow a smell; nose-leg coordination. Responding to sensory motor stimuli, on the other hand, gets into attention and executive function.
where to buy huperzine a
These are some of the reasons Huperzine was selected for PerformElite. Nootropics as a whole are lacking thorough research, and Huperzine is one of the most researched nootropics available. It is also considered extremely safe, which some nootropics are not (many are also stimulants). From personal experience, huperzine is one of the best for enhancing focus and attention during exercise. It helps with starting strong and staying in tune with the body throughout an exercise bout. On some training days, those 2 factors really make a difference!
For some years, huperzine A has been investigated as a possible treatment for diseases characterized by neurodegeneration, particularly Alzheimer's disease. A 2013 meta-analysis found that huperzine A may be efficacious in improving cognitive function, global clinical status, and activities of daily living for individuals with Alzheimer's disease. However, due to the poor size and quality of the clinical trials reviewed, huperzine A should not be recommended as a treatment for Alzheimer's disease unless further high quality studies confirm such findings.
Huperzine A may present with mild cholinergic side effects such as nausea, vomiting, and diarrhea. Slight muscle twitching and slurred speech might also occur, as well as excessive saliva excretion and sweating. The use of huperzine A during pregnancy and lactation is not recommended due to the lack of sufficient safety data.
Huperzine A may have additive effects if taken with drugs causing bradycardia, such as beta-blockers, which may decrease heart rate. Theoretically, there may be possible additive cholinergic effects if huperzine A is taken with other acetylcholinesterase inhibitors or cholinergic agents.
Huperzine A can increase a chemical in the body called acetylcholine. Acetylcholine plays a big part in many important body functions. Some medications, called anticholinergic drugs, block the effects of acetylcholine in the body. Taking huperzine A might decrease the effects of anticholinergic drugs.
Huperzine A can increase a chemical in the body called acetylcholine. Some medications that are used for glaucoma, Alzheimer disease, and other conditions, also increase acetylcholine levels. Taking huperzine A with these medications might increase the chance of side effects.
Little is known about the safety of taking huperzine A every day, long term. There is some concern that the use of huperzine A may be harmful to people with certain health conditions, including kidney and/or liver disorders, heart disease, asthma, epilepsy, and vertigo.
It is possible but not guaranteed that huperzine A will improve workout and exercise. Early studies suggest it may enhance concentration and focus, but there is a lack of supporting evidence to be certain of these benefits. The safety of the supplement is currently unknown.
Rafii MS, Walsh S, Little JT, et al; Alzheimer's Disease Cooperative Study. A phase II trial of huperzine A in mild to moderate Alzheimer disease. Neurology. 2011;76(16):1389-94. doi:10.1212/WNL.0b013e318216eb7b
A study published in a lesser-known Chinese journal in 1999 suggested that when a group of middle school students were given 200 mcg tablets of huperzine a over an 8-week period, it improved their memory in learning tasks .
Although some cancer patients use huperzine to reduce chemotherapy side effects, no clinical studies have been conducted to show it is safe and effective for such use. It may also interact with many drugs and can cause mild adverse effects.
Mild adverse effects from huperzine have been reported (7). Because it acts as an acetylcholinesterase inhibitor, it can potentially interact with many drugs including other anticholinergic drugs, dopamine D2 receptor blockers, calcium channel blockers, and beta adrenergic receptor antagonists (11).
Huperzine diminished diabetes-associated cognitive decline in rats by enhancing glycemic control, suppressing inflammation, augmenting brain-derived neurotrophic factor expression, and limiting oxidative stress (5). In a mouse model of hepatic ischemia reperfusion injury, the antioxidative, anti-inflammatory, and antiapoptotic properties of huperzine contributed to hepatoprotective effects (4).
Nausea, anorexia, dizziness, vomiting, constipation, insomnia, excitability, thirst, sweating, bradycardia, abdominal pain, somnolence, hyperactivity, nasal obstruction, diarrhea, and edema (21). Some of these reactions could stem from the anticholinesterase activity of huperzine A.
CYP450 substrates: Lab studies indicate huperzine A induces CYP3A4 by activating pregnane X receptor (22). This may reduce effectiveness of drugs metabolized by this enzyme. Clinical relevance has yet to be determined.Acetylcholinesterase inhibitors (donepezil, galantamine, rivastigmine): Huperzine A may increase risk of adverse events for other drugs that have acetylcholinesterase inhibition effects.Dopamine D2 receptor blockers: Taken in conjunction with acetylcholinesterase inhibitors, it may produce a dopamine/acetylcholine imbalance in the striatum, leading to parkinsonian symptoms (11).Calcium channel blockers: Because acetylcholinesterase inhibitors can produce bradycardia on their own, huperzine A and a calcium channel blocker may produce more severe bradycardia (11).Beta adrenergic receptor antagonists: Because acetylcholinesterase inhibitors can produce bradycardia on their own, huperzine A and a calcium channel blocker may produce more severe bradycardia (11).
They call for more, better-designed, studies to be done on this subject.9Yue J, Dong BR, Lin X, Yang M, Wu HM, Wu T. No evidence from randomised controlled trials for or against the use of huperzine A in the treatment of people with mild cognitive impairment Cochrane. 2012
It is also possible that Hup A can increase the effectiveness of other antioxidants as well. 12Xiao XQ, Wang R, Han YF, Tang XC. Protective effects of huperzine A on beta-amyloid(25-35) induced oxidative injury in rat pheochromocytoma cells. Neuroscience Letters. 2000
Luckily, there is clinical evidence that Hup A can increase levels of NGF in the brain. 13Tang LL, Wang R, Tang XC.. Effects of huperzine A on secretion of nerve growth factor in cultured rat cortical astrocytes and neurite outgrowth in rat PC12 cells. Acta Pharmacologica Seneca. 2005
The development program which will be referred to as SPN-817 will utilize a novel synthetic form of huperzine A which is a potent acetyl cholinesterase inhibitor with pharmacological activities in CNS conditions such as epilepsy. SPN-817 will have a new chemical entity status (NCE) in the U.S. market, and Supernus expects to have significant IP protecting this product candidate through its own research and development efforts as well as the in-licensed IP.
Supernus will focus on completing and optimizing the synthesis process of the drug and the development of a novel dosage form. Given the potency of huperzine A, a novel extended release oral dosage form is critical to the success of this program because initial studies with immediate release formulations of non-synthetic huperzine A have shown dose-limiting serious side effects.
Research on huperzine A is still ongoing and there is still much to learn about how it works and its effects on the brain. However, some studies have suggested that it can be beneficial for memory and cognition. In one study, huperzine A was found to improve the learning ability of rats with cognitive impairments.
Additionally, a meta-analysis of 30 studies found that huperzine A improved memory and cognitive performance in humans with Alzheimer's disease and other forms of dementia. Further research also suggests that huperzine A might be useful in treating age-related cognitive decline, as well as improving focus and alertness in healthy adults.
Research has also linked high intake of omega-3s to a possible reduction in risk of dementia or cognitive decline. The chief omega-3 in the brain is DHA, which is found in the fatty membranes that surround nerve cells, especially at the microscopic junctions where cells connect to one another.
Huperzine A benefits may be considered to be closely related to that of nicotine, as they both increase acetylcholine levels and are shown to increase cognition . However, these two alkaloids have vastly different effects on the body, and, unlike huperzine A, nicotine is a highly addictive CNS stimulant .
While several studies have found huperzine A to be fairly well-tolerated [19, 20], there are a few studies that suggest the contrary, where participants experienced more side effects when compared to placebo .
These mighty microbes come with hard-hitting effects of boosting cognition, improving memory, and reducing stress and anxiety in highly stressed adults . Like huperzine A, the benefits of cognitive function appear to be most significant in those already experiencing cognitive impairment [24, 25, 26].
However, unlike huperzine A, they have relatively no side effects, even when used daily and long-term. Even more, they have a wide-array of health benefits and are a safe and easy option for improving overall well-being.
A group of researchers in China conducted a randomized, double-blind, placebo-controlled study (11) on a small group of 28 patients suffering from AD. They reported the beneficial effect of huperzine A tablets given at a dose of 200 µg, twice a day for 60 days. Huperzine A treatment caused a 71.4% improvement in the cognitive evaluation (using WMS scale) as compared to 25.5% with the placebo (p 041b061a72